Best Peptides for Immune Support
Peptides that modulate immune function, enhance immune response, and support overall immune health.
Top Peptides for Immune Support
| Peptide | Evidence | Use Case | Actions |
|---|---|---|---|
| VIP (Vasoactive Intestinal Peptide)Top Choice VIP is a 28-amino acid neuropeptide with wide-ranging effects throughout the body. It acts as a neurotransmitter, neuromodulator, and immune regulator with particular importance in gut and lung function. | medium | Potent immunomodulatory effects, used in chronic inflammatory conditions | |
| Thymosin Alpha-1Top Choice Thymosin Alpha-1 is a peptide naturally produced by the thymus gland that plays a crucial role in immune system modulation. It is approved in over 35 countries for various conditions including hepatitis B and C. | high | Primary use case - extensive clinical evidence for immune modulation | |
| LL-37 (Cathelicidin)Top Choice LL-37 is the only human cathelicidin antimicrobial peptide. It plays crucial roles in innate immunity and has shown diverse biological activities including antimicrobial, immunomodulatory, and wound healing properties. | high | Primary antimicrobial and immunomodulatory peptide | |
| ThymalinTop Choice Thymalin is a polypeptide preparation derived from calf thymus. Developed in Russia, it has been used for decades to support immune function and has shown potential anti-aging effects in long-term studies. | high | Decades of clinical use for immune modulation in Eastern Europe | |
| Alpha-DefensinTop Choice Alpha-defensins are small cationic peptides that are key components of the innate immune system. They have broad-spectrum antimicrobial activity against bacteria, fungi, and some viruses. | high | Key innate immune peptide with broad antimicrobial activity | |
| LactoferricinTop Choice Lactoferricin is an antimicrobial peptide derived from lactoferrin, a protein found in milk and other secretions. It has potent antibacterial, antiviral, and antifungal properties. | high | Potent natural antimicrobial peptide from lactoferrin | |
| ThymulinTop Choice Thymulin (Facteur Thymique Sérique) is a zinc-dependent nonapeptide hormone produced by thymic epithelial cells. It plays important roles in T-cell differentiation and immune system maturation. | medium | Thymic hormone supporting T-cell function | |
| NA-Selank Amidate NA-Selank Amidate (N-Acetyl Selank Amidate) is an enhanced version of Selank with improved stability and blood-brain barrier penetration. The modifications increase bioavailability and duration of cognitive and anxiolytic effects. | low | Retains immunomodulatory properties of parent compound | |
| Selank Selank is a synthetic peptide derived from the naturally occurring immunomodulatory peptide tuftsin. Developed in Russia for anxiety and cognitive enhancement. | medium | Derived from tuftsin, has immunomodulatory properties | |
| Semax Semax is a synthetic peptide derived from ACTH (adrenocorticotropic hormone). Developed in Russia as a nootropic and neuroprotective agent. | low | Some evidence for immunomodulatory effects |
VIP is a 28-amino acid neuropeptide with wide-ranging effects throughout the body. It acts as a neurotransmitter, neuromodulator, and immune regulator with particular importance in gut and lung function.
Potent immunomodulatory effects, used in chronic inflammatory conditions
Thymosin Alpha-1 is a peptide naturally produced by the thymus gland that plays a crucial role in immune system modulation. It is approved in over 35 countries for various conditions including hepatitis B and C.
Primary use case - extensive clinical evidence for immune modulation
LL-37 is the only human cathelicidin antimicrobial peptide. It plays crucial roles in innate immunity and has shown diverse biological activities including antimicrobial, immunomodulatory, and wound healing properties.
Primary antimicrobial and immunomodulatory peptide
Thymalin is a polypeptide preparation derived from calf thymus. Developed in Russia, it has been used for decades to support immune function and has shown potential anti-aging effects in long-term studies.
Decades of clinical use for immune modulation in Eastern Europe
Alpha-defensins are small cationic peptides that are key components of the innate immune system. They have broad-spectrum antimicrobial activity against bacteria, fungi, and some viruses.
Key innate immune peptide with broad antimicrobial activity
Lactoferricin is an antimicrobial peptide derived from lactoferrin, a protein found in milk and other secretions. It has potent antibacterial, antiviral, and antifungal properties.
Potent natural antimicrobial peptide from lactoferrin
Thymulin (Facteur Thymique Sérique) is a zinc-dependent nonapeptide hormone produced by thymic epithelial cells. It plays important roles in T-cell differentiation and immune system maturation.
Thymic hormone supporting T-cell function
NA-Selank Amidate (N-Acetyl Selank Amidate) is an enhanced version of Selank with improved stability and blood-brain barrier penetration. The modifications increase bioavailability and duration of cognitive and anxiolytic effects.
Retains immunomodulatory properties of parent compound
Selank is a synthetic peptide derived from the naturally occurring immunomodulatory peptide tuftsin. Developed in Russia for anxiety and cognitive enhancement.
Derived from tuftsin, has immunomodulatory properties