PEG-MGF vs Sermorelin & GHRP-2 & GHRP-6
A detailed comparison to help you understand the differences and choose the right peptide for your research goals.
PEG-MGF
PEG-MGF (PEGylated Mechano Growth Factor) is a variant of IGF-1 that is produced in response to muscle damage. PEGylation extends its half-life from minutes to several hours, making it practical for use.
Full details →Sermorelin & GHRP-2 & GHRP-6
A powerful tri-blend combining Sermorelin (a GHRH analog) with two growth hormone releasing peptides. This combination produces significantly greater GH release than any single peptide, with studies showing up to 54-fold increases in pulsatile GH secretion.
Full details →Side-by-Side Comparison
| Aspect | PEG-MGF | Sermorelin & GHRP-2 & GHRP-6 |
|---|---|---|
| Mechanism | Activates muscle satellite cells (stem cells) and promotes their fusion to existing muscle fibers for repair and growth. MGF is produced naturally in response to mechanical stress on muscles. | Sermorelin stimulates the pituitary via GHRH receptors, while GHRP-2 and GHRP-6 act as ghrelin mimetics on different receptor subtypes. The combination creates synergistic GH release through multiple complementary pathways. GHRP-6 also strongly stimulates appetite. |
| Typical Dosage | Research protocols typically use 200-400mcg injected into targeted muscle groups 2-3 times weekly, usually post-workout. | Typical protocols: Sermorelin 100-300mcg, GHRP-2 100-300mcg, GHRP-6 100-300mcg. Often administered 2-3 times daily, 30 minutes before meals or at bedtime. |
| Administration | Intramuscular injection, ideally into muscles trained that day. Best administered post-workout when satellite cell activation is relevant. | Subcutaneous injection. Best administered fasted or before sleep to maximize natural GH cycle. The three peptides can be mixed together or administered separately. |
| Side Effects | Injection site soreness, potential hypoglycemia, and localized swelling. Generally well-tolerated. | Increased hunger (especially from GHRP-6), water retention, facial flushing, nausea, tingling, potential increases in cortisol and prolactin levels. |
| Best For |
What They Have in Common
Both PEG-MGF and Sermorelin & GHRP-2 & GHRP-6 are commonly used for: