Sermorelin & GHRP-2 & GHRP-6
A powerful tri-blend combining Sermorelin (a GHRH analog) with two growth hormone releasing peptides. This combination produces significantly greater GH release than any single peptide, with studies showing up to 54-fold increases in pulsatile GH secretion.
Mechanism of Action
Sermorelin stimulates the pituitary via GHRH receptors, while GHRP-2 and GHRP-6 act as ghrelin mimetics on different receptor subtypes. The combination creates synergistic GH release through multiple complementary pathways. GHRP-6 also strongly stimulates appetite.
Typical Dosage (Research)
Typical protocols: Sermorelin 100-300mcg, GHRP-2 100-300mcg, GHRP-6 100-300mcg. Often administered 2-3 times daily, 30 minutes before meals or at bedtime.
Subcutaneous injection. Best administered fasted or before sleep to maximize natural GH cycle. The three peptides can be mixed together or administered separately.
Side Effects & Risks
Increased hunger (especially from GHRP-6), water retention, facial flushing, nausea, tingling, potential increases in cortisol and prolactin levels.
Off-label use with limited clinical trial data. May affect natural GH regulation with long-term use. Not FDA approved for this combination.
Who Uses Sermorelin & GHRP-2 & GHRP-6
Those seeking significant GH elevation for anti-aging, muscle growth, improved body composition, and enhanced recovery. Athletes looking for alternatives to synthetic HGH.