HGH Fragment 176-191 vs Sermorelin & GHRP-2 & GHRP-6
A detailed comparison to help you understand the differences and choose the right peptide for your research goals.
HGH Fragment 176-191
HGH Fragment 176-191 is the fat-reducing portion of the growth hormone molecule. Unlike AOD-9604 (which has an additional tyrosine), this is the exact fragment of HGH responsible for lipolytic effects.
Full details →Sermorelin & GHRP-2 & GHRP-6
A powerful tri-blend combining Sermorelin (a GHRH analog) with two growth hormone releasing peptides. This combination produces significantly greater GH release than any single peptide, with studies showing up to 54-fold increases in pulsatile GH secretion.
Full details →Side-by-Side Comparison
| Aspect | HGH Fragment 176-191 | Sermorelin & GHRP-2 & GHRP-6 |
|---|---|---|
| Mechanism | Mimics the lipolytic region of growth hormone, stimulating fat breakdown and inhibiting lipogenesis without affecting blood sugar or promoting growth. Works independently of GH receptors. | Sermorelin stimulates the pituitary via GHRH receptors, while GHRP-2 and GHRP-6 act as ghrelin mimetics on different receptor subtypes. The combination creates synergistic GH release through multiple complementary pathways. GHRP-6 also strongly stimulates appetite. |
| Typical Dosage | Typical dosing: 250-500mcg daily, often split into 2-3 doses. Usually administered on empty stomach, often with fasted cardio. | Typical protocols: Sermorelin 100-300mcg, GHRP-2 100-300mcg, GHRP-6 100-300mcg. Often administered 2-3 times daily, 30 minutes before meals or at bedtime. |
| Administration | Subcutaneous injection. Best results when used fasted and combined with exercise. Avoid eating for 30 minutes post-injection. | Subcutaneous injection. Best administered fasted or before sleep to maximize natural GH cycle. The three peptides can be mixed together or administered separately. |
| Side Effects | Generally well-tolerated. May cause injection site irritation, temporary lethargy, or headache. Does not affect blood glucose significantly. | Increased hunger (especially from GHRP-6), water retention, facial flushing, nausea, tingling, potential increases in cortisol and prolactin levels. |
| Best For |
What They Have in Common
Both HGH Fragment 176-191 and Sermorelin & GHRP-2 & GHRP-6 are commonly used for: