CJC-1295 & Ipamorelin vs Epithalamin
A detailed comparison to help you understand the differences and choose the right peptide for your research goals.
CJC-1295 & Ipamorelin
The most popular growth hormone secretagogue combination. CJC-1295 (a GHRH analog) and Ipamorelin (a ghrelin mimetic) work synergistically to stimulate natural growth hormone release with potentially greater effects than either peptide alone.
Full details →Epithalamin
Epithalamin is a natural peptide extract from the pineal gland. It is the precursor compound from which the synthetic Epitalon was derived. Known for anti-aging and telomerase-activating properties.
Full details →Side-by-Side Comparison
| Aspect | CJC-1295 & Ipamorelin | Epithalamin |
|---|---|---|
| Mechanism | CJC-1295 binds to GHRH receptors to sustain GH signaling and extend the half-life of growth hormone release. Ipamorelin triggers strong GH pulses by binding to ghrelin receptors. Together, they create both sustained and pulsatile GH release patterns that more closely mimic natural physiology. | Similar to Epitalon, it stimulates telomerase production and may help maintain telomere length. Also regulates melatonin synthesis and circadian rhythms. |
| Typical Dosage | CJC-1295 (no DAC/Mod GRF 1-29): 100-300mcg combined with Ipamorelin 200-300mcg, administered 1-3 times daily. Best results when administered fasted or before sleep. | Research dosing: 10-20mg daily for 10-20 day cycles. Often administered 1-3 times per year in long-term protocols. |
| Administration | Subcutaneous injection. Often administered before bedtime to enhance natural nighttime GH release, or in the morning fasted. The combination is typically pre-mixed or injected simultaneously. | Intramuscular or subcutaneous injection. Natural extract may have more variable composition than synthetic Epitalon. |
| Side Effects | Water retention, tingling in extremities, mild headaches, lightheadedness, or increased hunger. Generally well-tolerated with minimal effect on cortisol or prolactin. | Generally well-tolerated. May affect sleep patterns. Less characterized than synthetic Epitalon. |
| Best For |
What They Have in Common
Both CJC-1295 & Ipamorelin and Epithalamin are commonly used for: